Technological factors influencing on production of pharmaceutical-grade carboxymethyl cellulose (CMC) from cotton cellulose

Nguyen Thi Viet Thanh; Nguyen Thu Tra; Ta Hong Duc

doi:10.15625/2525-2518/19579

Author affiliations

Authors

Nguyen Thi Viet Thanh School of Chemical Engineering, Hanoi University of Science and Technology, 1 Dai Co Viet, Bach Mai Ward, Ha Noi, Viet Nam
Nguyen Thu Tra School of Chemical Engineering, Hanoi University of Science and Technology, 1 Dai Co Viet, Bach Mai Ward, Ha Noi, Viet Nam
Ta Hong Duc School of Chemical Engineering, Hanoi University of Science and Technology, 1 Dai Co Viet, Bach Mai Ward, Ha Noi, Viet Nam https://orcid.org/0000-0003-3835-8545

DOI:

https://doi.org/10.15625/2525-2518/19579

Keywords:

carboxymethyl cellulose, cotton cellulose, pharmaceutical grade

Abstract

The effects of sodium hydroxide (NaOH) concentration, molar ratios of monochloroacetic acid (MCA) to anhydroglucose unit (AGU), molar ratios of NaOH to MCA, ethanol concentration, and volume on carboxymethyl cellulose (CMC) production were investigated. The results demonstrated that CMC with an average substitution degree of 0.9267 was obtained using 50 % (w/v) NaOH, a MCA/AGU molar ratio of 1.3, and a NaOH/MCA molar ratio of 3. The optimal washing process for achieving pharmaceutical-grade carboxymethyl cellulose involved a series of five washes with 60 mL of 80 % v/v ethanol, resulting in impurity residue consisting of sodium chloride (NaCl) and sodium glycolate (HNa) at 0.23 % and 0.19 %, respectively. This process represented the least amount of solvent required to attain pharmacopoeial standards for CMC purity, while also minimizing the number of washes needed to preserve the quality of the CMC product. These results offered a practical method for preparing high-purity CMC for use in the pharmaceutical industry.

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