Controlling the particle size and pore size of mesoporous SiO2 nanoparticles for enhanced drug loading efficiency

Pham Hoai Linh, Tran Thi Huong, Nguyen Hong Nhung, Nguyen Quoc Dung, Ta Ngoc Bach, Nguyen Thi Ngoc Anh, Nguyen Thanh Nam, Julia A. Fedotova, Nguyen Tien Dung
Author affiliations

Authors

  • Pham Hoai Linh \(^1\) Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Street, Nghia Do Ward, Ha Noi, Viet Nam
  • Tran Thi Huong \(^1\) Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Street, Nghia Do Ward, Ha Noi, Viet Nam https://orcid.org/0000-0003-2336-3448
  • Nguyen Hong Nhung \(^1\) Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Street, Nghia Do Ward, Ha Noi, Viet Nam
  • Nguyen Quoc Dung \(^2\) Faculty of Chemistry, Thai Nguyen University of Education, No. 20 Luong Ngoc Quyen Street, Phan Dinh Phung Ward, Thai Nguyen, Viet Nam https://orcid.org/0000-0003-0591-0516
  • Ta Ngoc Bach \(^1\) Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Street, Nghia Do Ward, Ha Noi, Viet Nam
  • Nguyen Thi Ngoc Anh \(^1\) Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Street, Nghia Do Ward, Ha Noi, Viet Nam
  • Nguyen Thanh Nam \(^3\) University of Transport Technology, 54 Trieu Khuc Street, Thanh Liet Ward, Ha Noi, Viet Nam
  • Julia A. Fedotova \(^4\) Institute for Nuclear Problems, Belarusian State University, Minsk 220006, Belarus
  • Nguyen Tien Dung \(^5\) Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Street, Cau Giay Ward, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/19779

Keywords:

SiO2 nanoparticles, surface area, particle size, pore size, drug loading

Abstract

In this work, we focus on synthesizing mesoporous SiO2 nanoparticles (NPs) with various sizes and pore sizes for enhancing BET surface area to apply in drug delivery by a simple modified Stöber method. By adjusting the ethanol content in the solvent mixture of cetyltrimethylammonium bromide (CTAB), four samples with particle sizes in a range of 50 nm to 350 nm and with average pore size in a range of 2.72 nm to 8.29 nm were obtained. The SiO2 NPs exhibit a mesoporous structure with an amorphous phase and perfect spherical morphology. The N2 adsorption-desorption analysis reveals that mesoporous SiO2 NPs display high BET surface values, which depend strongly on the synthesis condition as well as the particle diameters and pore sizes. The BET values increase from 848 m2/g to 1019 m2/g when the ethanol content in the solvents decreases from 20 % to 10 %. The loading properties of doxorubicin (DOX) were also investigated. The highest amount of loaded DOX achieved with a loading efficiency of 98 % was 99 μg/mg for the SiO2NPs with the smallest size. The results suggest that the high surface mesoporous SiO2 has great potential in drug delivery applications.

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Published

05-12-2025

How to Cite

Linh, P. H., Huong, T. T., Nhung, N. H., Dung, N. Q., Bach, T. N., Anh, N. T. N., … Dung, N. T. (2025). Controlling the particle size and pore size of mesoporous SiO2 nanoparticles for enhanced drug loading efficiency. Vietnam Journal of Science and Technology, 64(3), 486–495. https://doi.org/10.15625/2525-2518/19779

Issue

Vol. 64 No. 3 (2026)

Section

Materials

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