Flavonoids from the branches and leaves of <i>Erythrina variegata</i> L. and their PTP1B and α-glucosidase inhibitory activities

Trinh Ngoc Thao Vy; Ninh The Son; Do Thi Thuy; Hoang Thi Phuong; Pham Quynh Trang; Ha Thi Hai Yen; Tran Huu Huy; Hak-Cheol Kwon; Cheol-Ho Pan; Nguyen Ngoc Linh; Lam Vinh Nien; Phi-Hung Nguyen

doi:10.15625/2525-2518/21761

Author affiliations

Authors

Trinh Ngoc Thao Vy \(^1\) University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang, Cho Lon Ward, Ho Chi Minh, Viet Nam
\(^2\) Faculty of Medicine and Pharmacy, Tay Nguyen University, 567 Le Duan, Ea Kao Ward, Dak Lak, Viet Nam https://orcid.org/0009-0003-5629-7456
Ninh The Son \(^3\) Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do Ward, Ha Noi, Viet Nam https://orcid.org/0000-0002-2413-7496
Do Thi Thuy \(^3\) Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do Ward, Ha Noi, Viet Nam
Hoang Thi Phuong \(^3\) Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do Ward, Ha Noi, Viet Nam
Pham Quynh Trang \(^3\) Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do Ward, Ha Noi, Viet Nam
\(^4\) Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Nghia Do Ward, Ha Noi, Viet Nam
Ha Thi Hai Yen \(^3\) Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do Ward, Ha Noi, Viet Nam
Tran Huu Huy \(^3\) Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do Ward, Ha Noi, Viet Nam
Hak-Cheol Kwon \(^5\) Natural Product Research Institute, Korea Institute of Science and Technology, 679 Saimdang-ro, Gangeung, Gangwon-do, 25451, Republic of Korea
Cheol-Ho Pan \(^5\) Natural Product Research Institute, Korea Institute of Science and Technology, 679 Saimdang-ro, Gangeung, Gangwon-do, 25451, Republic of Korea
Nguyen Ngoc Linh \(^6\) Faculty of Pharmacy, Thanh Do University, Hoai Duc Ward, Ha Noi, Viet Nam
Lam Vinh Nien \(^1\) University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang, Cho Lon Ward, Ho Chi Minh, Viet Nam
Phi-Hung Nguyen \(^3\) Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do Ward, Ha Noi, Viet Nam
\(^4\) Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Nghia Do Ward, Ha Noi, Viet Nam https://orcid.org/0000-0002-6678-4253

DOI:

https://doi.org/10.15625/2525-2518/21761

Keywords:

Erythrina variegata, flavanones, PTP1B inhibitor, α-glucosidase

Abstract

Phytochemical investigation of the methanolic extract of the Vietnamese Erythrina variegata branches and leaves resulted in the separation and identification of five flavanones, including 7,4'-dihydroxy-3'-methoxyflavanone (1), abyssinone VII (2), sigmoidin B (3), aromadendrin (4), and sigmoidin D (5). Their chemical structures were confirmed by the nuclear magnetic resonance (NMR) spectral analysis. These isolated compounds showed inhibitory activities toward two enzymes PTP1B and α-glucosidase, exhibiting varying levels of inhibition. Especially, metabolite 2 strongly inhibited the two enzymes with IC₅₀ values of 8.34 ± 0.67 and 12.14 ± 0.39 µM, respectively. In general, hydroxylation at carbons C-5/C-3' and prenylation at C-3ʹ/C-5ʹ mainly caused active enhancements of these metabolites against both enzyme activities.

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