Controlled release and drug delivery potential of carrageenan/poly(lactic acid) composites for lovastatin

Vu Quoc Manh; Tran Thi Kieu Giang; Vu Thi Thuong; Doan Thi Yen; Bui Thanh Nga; Huynh Xuan Mai; Pham Nguyen Thao Nguyen; Nguyen Thi Hong Nhung; Nguyen Ngoc Linh; Nguyen Thi Bich Viet; Vu Thi Huong; Nguyen Dang Dat; Vu Quoc Trung

doi:10.15625/2525-2518/22611

Author affiliations

Authors

Vu Quoc Manh \(^1\) Faculty of Pharmacy, Thanh Do University, Kim Chung, Hoai Duc Ward, Ha Noi, Viet Nam https://orcid.org/0000-0003-3105-256X
Tran Thi Kieu Giang \(^2\) Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay Ward, Ha Noi, Viet Nam
Vu Thi Thuong \(^2\) Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay Ward, Ha Noi, Viet Nam
Doan Thi Yen \(^2\) Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay Ward, Ha Noi, Viet Nam
Bui Thanh Nga \(^2\) Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay Ward, Ha Noi, Viet Nam
Huynh Xuan Mai \(^2\) Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay Ward, Ha Noi, Viet Nam
Pham Nguyen Thao Nguyen \(^2\) Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay Ward, Ha Noi, Viet Nam
Nguyen Thi Hong Nhung \(^1\) Faculty of Pharmacy, Thanh Do University, Kim Chung, Hoai Duc Ward, Ha Noi, Viet Nam https://orcid.org/0009-0002-5519-3199
Nguyen Ngoc Linh \(^1\) Faculty of Pharmacy, Thanh Do University, Kim Chung, Hoai Duc Ward, Ha Noi, Viet Nam
Nguyen Thi Bich Viet \(^2\) Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay Ward, Ha Noi, Viet Nam https://orcid.org/0000-0001-6383-721X
Vu Thi Huong \(^2\) Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay Ward, Ha Noi, Viet Nam https://orcid.org/0000-0003-1387-2177
Nguyen Dang Dat \(^2\) Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay Ward, Ha Noi, Viet Nam
Vu Quoc Trung \(^2\) Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay Ward, Ha Noi, Viet Nam https://orcid.org/0000-0003-4629-0958

DOI:

https://doi.org/10.15625/2525-2518/22611

Keywords:

carrageenan, poly(lactic acid), lovastatin, drug delivery system, controlled drug release

Abstract

This study investigates the efficacy of poly(lactic acid)/carrageenan (PLA/Carr) composites in the encapsulation and controlled release of lovastatin (Lov). PLA/Carr/Lov composites were synthesized via a solution method with varying PLA/Carr ratios. The structural, morphological, thermal, and drug release properties of the composites were analyzed using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and ultraviolet-visible (UV-Vis) absorption spectroscopy. The results indicate that Lov was uniformly dispersed within the polymer matrix as nanoparticles ranging from 20 to 220 nm in size. Drug release studies in pH 2.0 and pH 7.4 environments revealed a biphasic release profile, consisting of an initial burst release followed by a sustained release phase. The PLA/Carr significantly influenced drug loading efficiency and release kinetics, with the optimal controlled release observed at a PLA/Carr ratio of 2:8. These findings highlight the potential of Carr/PLA composites as promising carriers for controlled drug delivery applications.

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