Investigation of antioxidant activity and yield optimization in <i>C. asiatica</i> extracts through maceration time variation for skin cream application

Ummul Habibah Hasyim; Tri Yuni Hendrawati; Renty Anugerah Mahaj Puteri; Ilham Mufandi; Cindy Emilia Putri

doi:10.15625/2525-2518/22376

Author affiliations

Authors

Ummul Habibah Hasyim \(^1\) Department of Chemical Engineering, Faculty of Engineering, Universitas Muhammadiyah Jakarta, Jalan Cempaka Putih Tengah 27, Jakarta, 10510, Indonesia
Tri Yuni Hendrawati \(^1\) Department of Chemical Engineering, Faculty of Engineering, Universitas Muhammadiyah Jakarta, Jalan Cempaka Putih Tengah 27, Jakarta, 10510, Indonesia
Renty Anugerah Mahaj Puteri \(^2\) Department of Industrial Engineering, Faculty of Engineering, Universitas Muhammadiyah Jakarta, Jalan Cempaka Putih Tengah 27, Jakarta, 10510, Indonesia
Ilham Mufandi \(^3\) Department of Agroindustrial Technology, Faculty of Science and Technology, Universitas Darussalam Gontor, Indonesia https://orcid.org/0000-0003-1201-5819
Cindy Emilia Putri \(^1\) Department of Chemical Engineering, Faculty of Engineering, Universitas Muhammadiyah Jakarta, Jalan Cempaka Putih Tengah 27, Jakarta, 10510, Indonesia

DOI:

https://doi.org/10.15625/2525-2518/22376

Keywords:

antioxidant, anti-aging cream, bioactive compound, C. asiatica, extraction

Abstract

The increasing demand for natural ingredients in cosmetic applications has highlighted Centella asiatica as a potential source of bioactive compounds with antioxidant properties. This study was evaluated the effect of maceration time on the extraction yield and antioxidant activity of C. asiatica using 70% ethanol as a solvent. Maceration periods of 18, 24, 30, 36, and 42 hours were investigated to determine the optimal extraction condition. The results showed that the 18-hour maceration produced the strongest antioxidant activity, indicated by the lowest IC50 value of approximately 25 µg/mL, whereas longer extraction times reduced activity due to possible degradation of bioactive compounds. FTIR analysis identified hydroxyl (O–H), carbonyl (C=O), and C–O functional groups associated with phenolic, flavonoid, and triterpenoid compounds. The extracts were incorporated into anti-aging cream formulations, which were evaluated for pH, viscosity, spreadability, moisture retention, and sensory properties. Formulation F4 exhibited the highest consumer acceptance with balanced physicochemical characteristics and antioxidant performance. These findings demonstrate that optimizing maceration time is essential for enhancing the bioactive potential of C. asiatica extracts for cosmetic applications.

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References

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